Last Exile is about.. I think airmail. I only saw four episodes.
I measure all television (and cinema, now, as well) against Cowboy Bebop. I'm of the opinion that the quality of Japanese anime really took a swan dive into a septic tank after Bebop. All the art is exactly identical, all the stories and characters are pretty derivative... It's boring.
I just like cartoons in general. Right now I have a lot more fun watching goofy TV like Adult Swim, and introducing people to serieses like Bebop and Trigun and shucks, even Love Hina, than I do with the new stuff.
I guess it boils down to me not being a fan of anime, but of high-quality entertainment media. Film, television, games, heck, even print novels - if it excells at being what it is, I'm probably into it. If it's trying to capture me with WOW MOTION BLUR HOLYFUCK GUNBATTLES IN SPACE I probably already saw it the first time.
But let's see what my collection is...
Manly:
Cowboy Bebop
Trigun
Hellsing
Girly:
Love Hina
Chobits
Hand Maid May
Hades made me buy it:
Crest of the Stars
Defies description:
FLCL
Oh, and because it relates somewhat:
Battle Angel Alita - I didn't see the reputedly awful anime rendition, and this is the only manga I've read so far (Byydo forced it on me,) but I'm confident it has no equal.
Back to the original topic... Without a doubt my favorite anime is Cowboy Bebop. It'll probably never see its equal.